• January 13, 2021

    PARADIGM OF SATURATED FATS AND CHOLESTEROL Part 5: Statins and their Side Effects

    For at least 60 years it has been erroneously established that high blood cholesterol, associated with saturated fat intake, is responsible for heart disease. For this reason, millions of people around the world, under medical advice, resort to statin therapy. In line with official guidelines, the use of statins is aimed at controlling the plasma cholesterol level, especially of the Low Density Lipoprotein (LDL) fraction, supposedly to decrease the incidence of cardiovascular diseases and deaths. However, data from several meta-analyses of randomized controlled and observational trials conducted over the last few decades have failed to demonstrate that reducing saturated fat intake is actually beneficial in lowering cholesterol. Furthermore, there is no statistical correlation and causality between high cholesterol and cardiovascular disease. In addition, while many scientific articles highlight the safety of statins, others point to their many side effects, calling into question the validation of their use. This review presents and discusses the potential side effects of statins, as well as other important issues related to this therapeutic procedure.

  • November 12, 2020

    THE USE OF CANNABINOIDS AS AN ADJUVANT IN THE TREATMENT OF ALZHEIMER’S DISEASE

    Alzheimer's disease is a common cause of dementia in the elderly, characterized by neuropsychiatric symptoms related to neuroanatomical and biochemical changes in the cerebral cortex. Drug treatment has little efficacy in more advanced stages of the disease, which leads to the search for adjunctive resources. The endocannabinoid system has gained great scientific prominence as a therapeutic target in the treatment of Alzheimer's disease, its components being highly associated with the pathophysiology of the disease. The purpose of this.....

  • October 15, 2019

    THE USE OF CANNABINOIDS AS AN ADJUVANT IN THE TREATMENT OF CHRONIC PAIN

    Historical records report the use of cannabis for pain treatment around 3000 BC. However, only in the 1960s, the active components of cannabis (CBD, THC, and 100 others) were described by scientists, and finally, in 1980, the first endogenous cannabinoid, anandamide (AEA), was identified, which reiterated the significance of the cannabinoid receptor and its endogenous ligands in controlling a wide variety of biological activities...

  • July 11, 2019

    THE MYTH OF SATURATED FAT AND CHOLESTEROL: SIX DECADES OF DECEPTION THAT HAS HARMED PEOPLE’S HEALTH AND WELL-BEING PART 1: DEBUNKING THE MYTH

    In the early 1950s, a new paradigm in health care was established: saturated fats and cholesterol are harmful because they are the primary causes of cardiovascular disease. Clinical and meta-analysis studies, however, have shown otherwise. In fact, these substances, obtained from food sources or endogenously, are essential for physiological performance and good health. The concept that its ingestion should be avoided is a...