For at least 60 years it has been erroneously established that high blood cholesterol, associated with saturated fat intake, is responsible for heart disease. For this reason, millions of people around the world, under medical advice, resort to statin therapy. In line with official guidelines, the use of statins is aimed at controlling the plasma cholesterol level, especially of the Low Density Lipoprotein (LDL) fraction, supposedly to decrease the incidence of cardiovascular diseases and deaths. However, data from several meta-analyses of randomized controlled and observational trials conducted over the last few decades have failed to demonstrate that reducing saturated fat intake is actually beneficial in lowering cholesterol. Furthermore, there is no statistical correlation and causality between high cholesterol and cardiovascular disease. In addition, while many scientific articles highlight the safety of statins, others point to their many side effects, calling into question the validation of their use. This review presents and discusses the potential side effects of statins, as well as other important issues related to this therapeutic procedure.

About the author : Reinaldo Souza

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