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Scientific Articles2022-12-20T10:57:55-03:00

PARADIGM OF SATURATED FATS AND CHOLESTEROL Part 5: Statins and their Side Effects

For at least 60 years it has been erroneously established that high blood cholesterol, associated with saturated fat intake, is responsible for heart disease. For this reason, millions of people around the world, under medical advice, resort to statin therapy. In line with official guidelines, the use of statins is aimed at controlling the plasma cholesterol level, especially of the Low Density Lipoprotein (LDL) fraction, supposedly to decrease the incidence of cardiovascular diseases and deaths. However, data from several meta-analyses of randomized controlled and observational trials conducted over the last few decades have failed to demonstrate that reducing saturated fat intake is actually beneficial in lowering cholesterol. Furthermore, there is no statistical correlation and causality between high cholesterol and cardiovascular disease. In addition, while many scientific articles highlight the safety of statins, others point to their many side effects, calling into question the validation of their use. This review presents and discusses the potential side effects of statins, as well as other important issues related to this therapeutic procedure.

THE USE OF CANNABINOIDS AS AN ADJUVANT IN THE TREATMENT OF ALZHEIMER’S DISEASE

Alzheimer's disease is a common cause of dementia in the elderly, characterized by neuropsychiatric symptoms related to neuroanatomical and biochemical changes in the cerebral cortex. Drug treatment has little efficacy in more advanced stages of the disease, which leads to the search for adjunctive resources. The endocannabinoid system has gained great scientific prominence as a therapeutic target in the treatment of Alzheimer's disease, its components being highly associated with the pathophysiology of the disease. The purpose of this.....

SATURATED FAT AND CHOLESTEROL PARADIGM PART 4: CHRONIC INFLAMMATION CAUSED BY CARBOHYDRATES

This is the fourth review article in the series that aims to break the paradigms related to the possible harm caused by saturated fats and cholesterol in human health. Topics are presented on the excessive intake of carbohydrates (sugars), considered to be the cause of organ imbalances and obesity, which lead to metabolic diseases such as cardiovascular diseases, type 2 diabetes, and hepatic steatosis, and worsen with metabolic syndrome and its comorbidities. Traditionally, obesity...

UNRAVELING THE SATURATED FAT AND CHOLESTEROL PARADIGM PART 3: CHRONIC INFLAMMATION CAUSED BY OMEGA-6, TRANS FATS AND LIPID PEROXIDATION

This is the third review article in the series that aims to break the paradigms related to the possible harm caused by saturated fats and cholesterol in human health. Scientific data on omega-6, omega-3, and trans fats and the phenomenon of lipid peroxidation are presented and discussed, as well as their influence on chronic inflammation. It has been wrongly established in recent decades that saturated fats and cholesterol are the cause of cardiovascular and related diseases. A new scientific theory, however, holds that these diseases...

UNRAVELING THE SATURATED FAT AND CHOLESTEROL PARADIGM PART 2: BIOCHEMICAL AND PHYSIOLOGICAL IMPORTANCE AND SOME PATHOLOGICAL CONSEQUENCES OF THE LACK OF THESE MOLECULES

This is the second article in the series that aims to break the paradigms related to the supposed harm caused by saturated fats and cholesterol to health. These substances, in fact, are present in human biochemistry and physiology, a fact that makes them essential for homeostasis. In case of intake deficit, they are produced endogenously, as they participate in numerous organic reactions, including structuring, fluidity and permeabilization of cell membranes, brain plasticity, nerve protection and communication, hormone formation[...].

THE USE OF CANNABINOIDS AS AN ADJUVANT IN THE TREATMENT OF CHRONIC PAIN

Historical records report the use of cannabis for pain treatment around 3000 BC. However, only in the 1960s, the active components of cannabis (CBD, THC, and 100 others) were described by scientists, and finally, in 1980, the first endogenous cannabinoid, anandamide (AEA), was identified, which reiterated the significance of the cannabinoid receptor and its endogenous ligands in controlling a wide variety of biological activities...

THE MYTH OF SATURATED FAT AND CHOLESTEROL: SIX DECADES OF DECEPTION THAT HAS HARMED PEOPLE’S HEALTH AND WELL-BEING PART 1: DEBUNKING THE MYTH

In the early 1950s, a new paradigm in health care was established: saturated fats and cholesterol are harmful because they are the primary causes of cardiovascular disease. Clinical and meta-analysis studies, however, have shown otherwise. In fact, these substances, obtained from food sources or endogenously, are essential for physiological performance and good health. The concept that its ingestion should be avoided is a...

NEW CONCEPTS ON NITRATES AND NITRITES

Used mainly by the meat industry, nitrates and nitrites are the oldest and most important food additives. With broad applications and functionalities, these components act as preservatives, antioxidants, color and flavor agents, besides promoting physicochemical and microbiological stability to the products. Companies and consumers, for years, have benefited from the varied action of these ingredients. ...

EGG – TO EAT OR NOT TO EAT?

Symbolically, the egg has multiple meanings - rebirth, fertility, universality, creation of life, luck, happiness. But it is in food that the egg concentrates its greatest benefit, with nutrients capable of promoting health and quality of life. The culinary interest in this delicacy dates back to approximately 3,200 B.C., a period associated with the beginning of the domestication of chickens. Over the years, it gained success at Mesopotamian era banquets, gaining several versions of preparation, thanks to its versatility. Specifically...

SCIENTIFIC TRUTH ABOUT A FUNCTIONAL SUPERFOOD CALLED COCONUT OIL

Data available in numerous books and globally recognized scientific papers - some of which are presented and discussed in this article - place coconut oil in the category now classified as a functional superfood. Despite its benefits, it is a food that is still underutilized due to the lack of knowledge of consumers, including, in this case, medical professionals, who, in their majority, do not receive training focused on the nutritional area.

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